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Article

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

European journal of immunology - 1 Jun 1994

Rada C, González-Fernández A, Jarvis J M, Milstein C

Abstract excerpt

The maturation of the immune response involves the hypermutation of antibody genes and the selection of B cells expressing receptors with improved antigen binding properties. Somatic hypermutation of antibody genes is targeted to a small region approximately 1 kb surrounding the rearranged V gene. The precise definition of the 5' limit is not yet clear since the data base of somatic mutations upstream of the V...

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PMID: 8206104
DOI: 10.1002/eji.1830240632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.PMID 8206104Read ↗

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Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.Semantic proximity Read ↗

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