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Article

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

European journal of immunology - 1 Jun 1994

Rada C, González-Fernández A, Jarvis J M, Milstein C

Abstract excerpt

The maturation of the immune response involves the hypermutation of antibody genes and the selection of B cells expressing receptors with improved antigen binding properties. Somatic hypermutation of antibody genes is targeted to a small region approximately 1 kb surrounding the rearranged V gene. The precise definition of the 5' limit is not yet clear since the data base of somatic mutations upstream of the V...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA Mutational Analysis
Genes, Immunoglobulin
Hybridomas
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Introns
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 8206104
DOI: 10.1002/eji.1830240632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8206104-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.PMID 8206104Read ↗

The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription.Semantic proximity Read ↗

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.Semantic proximity Read ↗

Kinetics of somatic mutation in lymph node germinal centres.Semantic proximity Read ↗

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.Semantic proximity Read ↗

Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.Semantic proximity Read ↗

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Semantic proximity Read ↗

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.Semantic proximity Read ↗

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Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.Semantic proximity Read ↗

Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene.Semantic proximity Read ↗

Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene.Semantic proximity Read ↗

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