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Article

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.

European journal of immunology - 1 Sept 1993

Rothenfluh H S, Taylor L, Bothwell A L, Both G W, Steele E J

Abstract excerpt

The aim of this study has been to determine the distribution of somatic mutations in the 5' flanking regions of rearranged immunoglobulin heavy chain variable region genes (VDJ). We sequenced the 5' flanking region in 12 secondary immune response antibodies produced in C57BL/6j mice against the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP) coupled to chicken-gamma-globulin. In these and previously published...

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PMID: 8370398
DOI: 10.1002/eji.1830230916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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