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Article

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.

European journal of immunology - 1 Sept 1993

Rothenfluh H S, Taylor L, Bothwell A L, Both G W, Steele E J

Abstract excerpt

The aim of this study has been to determine the distribution of somatic mutations in the 5' flanking regions of rearranged immunoglobulin heavy chain variable region genes (VDJ). We sequenced the 5' flanking region in 12 secondary immune response antibodies produced in C57BL/6j mice against the h...

Topics

Animals
Base Sequence
Blotting, Southern
Codon
DNA-Directed DNA Polymerase
Gene Deletion
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Mice
Mice, Inbred C57BL
Molecular Sequence Data

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Mutation

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Identifiers

PMID: 8370398
DOI: 10.1002/eji.1830230916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8370398-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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