Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.

Nucleic acids research - 15 May 1997

Jolly C J, Klix N, Neuberger M S

Abstract excerpt

Hypermutation of immunoglobulin genes is a key process in antibody diversification. Little is known about the mechanism, but the availability of rapid facile assays for monitoring immunoglobulin hypermutation would greatly aid the development of culture systems for hypermutating B cells as well as the screening for individuals deficient in the process. Here we describe two such assays. The first exploits the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to B-Lymphocytes
Share to Codon

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9115357
DOI: 10.1093/nar/25.10.1913
PMCID: PMC146691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.PMID 9115357Read ↗

Directed molecular evolution by somatic hypermutation.Semantic proximity Read ↗

Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.Semantic proximity Read ↗

Monitoring and interpreting the intrinsic features of somatic hypermutation.Semantic proximity Read ↗

Improved methods for detecting selection by mutation analysis of Ig V region sequences.Semantic proximity Read ↗

Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism.Semantic proximity Read ↗

Cellular and molecular studies of B cells exhibiting reverse somatic mutation throughout life.Semantic proximity Read ↗

Somatic hypermutation and the three R's: repair, replication and recombination.Semantic proximity Read ↗

Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin ĸ light chain genesSemantic proximity Read ↗

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin genes.Semantic proximity Read ↗

Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.