Article
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.
Nucleic acids research - 15 May 1997
Jolly C J, Klix N, Neuberger M S
Abstract excerpt
Hypermutation of immunoglobulin genes is a key process in antibody diversification. Little is known about the mechanism, but the availability of rapid facile assays for monitoring immunoglobulin hypermutation would greatly aid the development of culture systems for hypermutating B cells as well a...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- Cell Adhesion Molecules
- Codon
- Gene Rearrangement
- Genes, Immunoglobulin
- Genetic Variation
- Immunoglobulin J-Chains
- Immunoglobulin Variable Region
- Lectins
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Peyer's Patches
- Point Mutation