Article
Kinetics of somatic mutation in lymph node germinal centres.
Scandinavian journal of immunology - 1 Nov 1994
Källberg E, Gray D, Leanderson T
Abstract excerpt
Somatic mutation activity in immunoglobulin V kappa genes during the response to the hapten 2-phenyl-5-oxazolone was measured in lymph node B-cell populations at various timepoints after footpad immunization. When the V kappa Ox1 genes rearranged to the J kappa 5 segment were amplified from genom...
Topics
- Animals
- Apoptosis
- B-Lymphocytes
- Base Sequence
- Cells, Cultured
- DNA
- Gene Rearrangement, B-Lymphocyte
- Haptens
- Histocompatibility Antigens Class II
- Immunoenzyme Techniques
- Immunoglobulin kappa-Chains
- Lymph Nodes
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Oxazolone