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Article

Kinetics of somatic mutation in lymph node germinal centres.

Scandinavian journal of immunology - 1 Nov 1994

Källberg E, Gray D, Leanderson T

Abstract excerpt

Somatic mutation activity in immunoglobulin V kappa genes during the response to the hapten 2-phenyl-5-oxazolone was measured in lymph node B-cell populations at various timepoints after footpad immunization. When the V kappa Ox1 genes rearranged to the J kappa 5 segment were amplified from genomic DNA using the polymerase chain reaction and sequenced, somatic mutations could be detected as early as day 4 after...

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Identifiers

PMID: 7973453
DOI: 10.1111/j.1365-3083.1994.tb03492.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Kinetics of somatic mutation in lymph node germinal centres.PMID 7973453Read ↗

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.Semantic proximity Read ↗

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone.Semantic proximity Read ↗

Low antigen dose favours selection of somatic mutants with hallmarks of antibody affinity maturation.Semantic proximity Read ↗

Extensive somatic mutation in the Ig heavy chain V genes in a late primary anti-hapten immune response.Semantic proximity Read ↗

Mutation and selection during the secondary response to 2-phenyloxazolone.Semantic proximity Read ↗

Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center.Semantic proximity Read ↗

Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants.Semantic proximity Read ↗

Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization.Semantic proximity Read ↗

Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies.Semantic proximity Read ↗

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen.Semantic proximity Read ↗

Somatic diversity of the immunoglobulin repertoire is controlled in an isotype-specific manner.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.Semantic proximity Read ↗

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