Article
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.
Immunity - 1 Jan 1996
Peters A, Storb U
Abstract excerpt
To identify DNA sequences that target the somatic hypermutation process, the immunoglobulin gene promoter located upstream of the variable (V) region was duplicated upstream of the constant (C) region of a kappa transgene. Normally, kappa genes are somatically mutated only in the VJ region, but not in the C region. In B cell hybridomas from mice with this kappa transgene (P5'C), both the VJ region and the C...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Hybridomas
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Sequence Analysis
- Transcriptional Activation
- Transgenes