Article
Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 1994
González-Fernández A, Gupta S K, Pannell R, Neuberger M S, Milstein C
Abstract excerpt
The rate and nature of hypermutation of immunoglobulin genes are of prime importance in the affinity maturation of antibodies. Although a considerable body of information has been gathered for kappa light chains, there is much less data for lambda chains. We have derived a large data base of somatic mutants of mouse lambda 1 light chains from Peyer's patches germinal center B cells. The endogenous lambda 1 genes...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Immunoglobulin lambda-Chains
- Introns
- Mice
- Mice, Inbred C57BL