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Article

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

The EMBO journal - 1 Aug 1991

Sharpe M J, Milstein C, Jarvis J M, Neuberger M S

Abstract excerpt

We have compared the pattern of somatic mutation in different immunoglobulin kappa transgenes and suggest that an element(s) located between 1 kb and 9 kb 3' of C kappa is necessary for somatic hypermutation of the antibody V gene. The sequences of transgenic and endogenous Ig V regions were determined in antigen-specific B cell hybridomas specific for 2-phenyloxazolone from independent lines of hyperimmunized...

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Identifiers

PMID: 1905999
DOI: 10.1002/j.1460-2075.1991.tb07748.x
PMCID: PMC452901

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Source receipt: pubmed, retrieved 7 Sept 2026.

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