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Article

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

The EMBO journal - 1 Aug 1991

Sharpe M J, Milstein C, Jarvis J M, Neuberger M S

Abstract excerpt

We have compared the pattern of somatic mutation in different immunoglobulin kappa transgenes and suggest that an element(s) located between 1 kb and 9 kb 3' of C kappa is necessary for somatic hypermutation of the antibody V gene. The sequences of transgenic and endogenous Ig V regions were dete...

Topics

Amino Acid Sequence
Animals
B-Lymphocytes
Base Sequence
DNA
Fluorescent Antibody Technique
Genes, Immunoglobulin
Hybridomas
Immunoglobulin Constant Regions
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Molecular Sequence Data

Mutation

Staphylococcal Protein A

Source

Open in PubMed Open full text

Identifiers

PMID: 1905999
DOI: 10.1002/j.1460-2075.1991.tb07748.x
PMCID: PMC452901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1905999-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.PMID 1905999Read ↗

Lack of somatic mutation in a kappa light chain transgene.Semantic proximity Read ↗

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.Semantic proximity Read ↗

Analysis of somatic mutations in kappa transgenes.Semantic proximity Read ↗

Somatic hypermutation of an immunoglobulin mu heavy chain transgene.Semantic proximity Read ↗

Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes.Semantic proximity Read ↗

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.Semantic proximity Read ↗

Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene.Semantic proximity Read ↗

Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.Semantic proximity Read ↗

Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches.Semantic proximity Read ↗

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.Semantic proximity Read ↗

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.Semantic proximity Read ↗

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