Article
Comparison of mutation spectra induced by N-ethyl-N-nitrosourea in the hprt gene of Mer+ and Mer- diploid human fibroblasts.
Carcinogenesis - 1 May 1994
Yang J L, Lee P C, Lin S R, Lin J G
Abstract excerpt
N-Ethyl-N-nitrosourea (ENU) forms several major adducts upon reaction with DNA, of which ethylation at the O6 position of guanine and the O4, O2 and N3 positions of thymine have been implicated to be mutagenic lesions. To investigate what specific kinds of ENU-induced mutations were affected by t...
Topics
- Base Sequence
- DNA Ligases
- DNA Repair
- DNA Replication
- Diploidy
- Ethylnitrosourea
- Fibroblasts
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Methylnitronitrosoguanidine
- Methyltransferases
- Molecular Sequence Data
- Mutagenesis
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Phenotype
- Sensitivity and Specificity