Article
A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.
Carcinogenesis - 1 Aug 1993
Lefebvre P, Laval F
Abstract excerpt
The involvement of O6-methylguanine (O6-meGua) in mutagenesis is well established, while the toxic effect of these residues is still controversial. In this study, we compare the cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) on three cell lines of dif...
Topics
- Alkylating Agents
- Animals
- CHO Cells
- Carcinoma, Hepatocellular
- Cell Death
- Cell Division
- Cricetinae
- DNA Damage
- DNA Repair
- Drug Hypersensitivity
- Drug Resistance
- Guanine
- Humans
- Liver Neoplasms
- Liver Neoplasms, Experimental
- Methylnitronitrosoguanidine
- Methylnitrosourea
- Methyltransferases