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Article

A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.

Carcinogenesis - 1 Aug 1993

Lefebvre P, Laval F

Abstract excerpt

The involvement of O6-methylguanine (O6-meGua) in mutagenesis is well established, while the toxic effect of these residues is still controversial. In this study, we compare the cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) on three cell lines of different origin, which have different abilities to repair O6-meGua residues (Mer phenotype): a human hepatoma cell line...

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Identifiers

PMID: 8394782
DOI: 10.1093/carcin/14.8.1671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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