Article
Quantitative relationship between ethylated DNA bases and gene mutation at two loci in CHO cells.
Environmental and molecular mutagenesis - 1 Jan 1993
Fortini P, Calcagnile A, Di Muccio A, Bignami M, Dogliotti E
Abstract excerpt
In a previous study we showed that the formation of O6-ethylguanine (O6-EtGua) in the DNA of CHO cells in culture correlated with mutations induced by ethylnitrosourea (ENU) and diethylsulfate (DES) at the hypoxanthine-guanine-phosphoribosyltransferase (hprt) locus but not at the Na, K-ATPase loc...
Topics
- Adenine
- Alkylating Agents
- Alkylation
- Animals
- CHO Cells
- Chromatography, High Pressure Liquid
- Cricetinae
- DNA
- Dose-Response Relationship, Drug
- Ethyl Methanesulfonate
- Ethylnitrosourea
- Guanine
- Hypoxanthine Phosphoribosyltransferase
- Mutagenicity Tests
- Mutation
- Sodium-Potassium-Exchanging ATPase
- Sulfuric Acid Esters