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Article

Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene.

Carcinogenesis - 1 Oct 1991

Zhang L H, Jenssen D

Abstract excerpt

The reaction product of N-methyl-N-nitrosourea (MNU) with DNA, O6-methylguanine (O6-MeG), is responsible for the mutagenic and carcinogenic effects of this carcinogen. These involve activation of the H-ras proto-oncogene in rat mammary tumors by MNU, with a high frequency of GC to AT transitions in codon 12 of this gene. The present study aimed to investigate the types and position specificities of mutations...

Topics

Animals
Base Sequence
Blotting, Southern
Cells, Cultured
Cricetinae
Cricetulus
DNA
Exons
Genes
Hypoxanthine Phosphoribosyltransferase
Methylnitrosourea
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Polymerase Chain Reaction

RNA, Messenger

Source

Identifiers

PMID: 1934271
DOI: 10.1093/carcin/12.10.1903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1934271-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene.PMID 1934271Read ↗

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