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Article

Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene.

Carcinogenesis - 1 Oct 1991

Zhang L H, Jenssen D

Abstract excerpt

The reaction product of N-methyl-N-nitrosourea (MNU) with DNA, O6-methylguanine (O6-MeG), is responsible for the mutagenic and carcinogenic effects of this carcinogen. These involve activation of the H-ras proto-oncogene in rat mammary tumors by MNU, with a high frequency of GC to AT transitions in codon 12 of this gene. The present study aimed to investigate the types and position specificities of mutations...

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Identifiers

PMID: 1934271
DOI: 10.1093/carcin/12.10.1903

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