Article
On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line.
Mutation research - 1 Mar 1994
Rasouli-Nia A, Sibghat-Ullah, Mirzayans R, Paterson M C, Day R S
Abstract excerpt
O6-Methylguanine (m6G) is an altered base produced in DNA by SN1 methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). This lesion is repaired by the protein O6-methylguanine-DNA methyltransferase (MGMT) in normal human cell lines, but is not repaired in certain human tumor lines that are termed Mex- or Mer-. Compared with repair-proficient cell lines, such repair-deficient tumor lines are...
Topics
- Base Sequence
- Cell Death
- DNA
- DNA Repair
- Guanine
- Humans
- Methylnitronitrosoguanidine
- Methyltransferases
- Molecular Sequence Data
- Mutagens
- Mutation