Article
Effect of nucleotide excision repair on hprt gene mutations in rodent cells exposed to DNA ethylating agents.
Mutagenesis - 1 Nov 1997
Op het Veld C W, van Hees-Stuivenberg S, van Zeeland A A, Jansen J G
Abstract excerpt
The role of the nucleotide excision repair (NER) pathway in removal of DNA ethylation damage was investigated by means of hprt mutational spectra analysis in the NER-deficient Chinese hamster ovary cell line UV5, which lacks ERCC2/XPD, and in its parental cell line AA8. Both cell lines were expos...
Topics
- Alkylating Agents
- Animals
- CHO Cells
- Cricetinae
- DNA
- DNA Damage
- DNA Mutational Analysis
- DNA Repair
- Ethyl Methanesulfonate
- Ethylnitrosourea
- Genes
- Guanine
- Hypoxanthine Phosphoribosyltransferase
- Mutagenicity Tests
- Mutagens
- Mutation
- Species Specificity
- Thymine