Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.

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Article

Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.

Cancer research - 1 Oct 1991

Bronstein S M, Cochrane J E, Craft T R, Swenberg J A, Skopek T R

Abstract excerpt

We examined the toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea (ENU) in three Epstein-Barr virus-transformed human lymphoblastoid cell lines, each with a different DNA repair phenotype. One cell line lacks O6-alkylguanine-DNA alkyltransferase (AGT) activity; another, derived from a patient with xeroderma pigmentosum, complementation group A, lacks nucleotide exicision repair (NER)...

Topics

Adolescent
Adult
Base Sequence
Cell Division
Cell Survival
Cell Transformation, Viral
Cells, Cultured
Cloning, Molecular
DNA
DNA Repair
Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ethylnitrosourea

Female

Herpesvirus 4, Human

Humans

In Vitro Techniques

Male

Methyltransferases

Source

Open in PubMed

Identifiers

PMID: 1655249

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655249-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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