Article
Molecular characterization of mutations in the hprt gene of normal human skin keratinocytes treated with N-ethyl-N-nitrosourea: influence of O6-alkylguanine alkyltransferase.
Environmental and molecular mutagenesis - 1 Jan 1997
Tong H H, Park J H, Brady T, Weghorst C M, D'Ambrosio S M
Abstract excerpt
O6-Alkylguanine-DNA alkyltransferase (AGT) is responsible for repairing the O6-alkylguanine lesion in DNA. There is wide variation in the levels of AGT between organ and cell types, which appears to correlate with cell and tissue type sensitivity to the mutagenic and carcinogenic effects of alkyl...
Topics
- Cell Line
- Ethylnitrosourea
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Keratinocytes
- Methyltransferases
- Mutagens
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Sequence Analysis, DNA
- Skin