Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of spontaneous, gamma ray- and ethylnitrosourea-induced hprt mutants in HL-60 cells with multiplex PCR.

World journal of gastroenterology - 1 Mar 2003

Liu Sheng-Xue, Cao Jia, An Hui, Shun Hua-Min, Yang Lu-Jun, Liu Yong

Abstract excerpt

AIM: To explore the molecular spectra and mechanism of human hypoxanthine guanine phosphoribosyl transferase (hprt) gene mutation induced by ethyluitrosourea (ENU) and (60)Co gamma-rays. METHODS: Independent human promyelocytic leukemia cells (HL-60) mutants at the hprt locus were isolated from untreated, ethyluitrosourea (ENU) and (60)Co gamma-ray-exposed cells, respectively, and verified by two-way screening....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkylating Agents
Share to Ethylnitrosourea

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gamma Rays

Share to HL-60 Cells

Share to Hypoxanthine Phosphoribosyltransferase

Share to Mutation

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 12632522
DOI: 10.3748/wjg.v9.i3.578
PMCID: PMC4621586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of spontaneous, gamma ray- and ethylnitrosourea-induced hprt mutants in HL-60 cells with multiplex PCR.PMID 12632522Read ↗

Effect of ethylnitrosourea on HPRT gene in human promyelocytic leukemia cells.Semantic proximity Read ↗

Technical Report: A Simple and Robust Real-Time Quantitative PCR Method for the Detection of Radiation-Induced Multiple Exon Deletions of the Human HPRT Gene.Semantic proximity Read ↗

Sequence analysis of X-ray-induced mutations occurring in a cDNA of the human hprt gene integrated into mammalian chromosomal DNA.Semantic proximity Read ↗

Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells.Semantic proximity Read ↗

Molecular markers of ionizing radiation-induced gene mutations in mammalian cells.Semantic proximity Read ↗

Multiplex polymerase chain reaction-based deletion analysis of spontaneous, gamma ray- and alpha-induced hprt mutants of CHO-K1 cells.Semantic proximity Read ↗

Polymerase chain reaction-based comprehensive procedure for the analysis of the mutation spectrum at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster cells.Semantic proximity Read ↗

Mammalian cell HPRT gene mutation assay: test methods.Semantic proximity Read ↗

Molecular analysis of hprt mutations generated in Chinese hamster ovary EM9 cells by uranyl acetate, by hydrogen peroxide, and spontaneously.Semantic proximity Read ↗

Comparison of mutation spectra induced by N-ethyl-N-nitrosourea in the hprt gene of Mer+ and Mer- diploid human fibroblasts.Semantic proximity Read ↗

Distinct mechanisms lead to HPRT gene mutations in leukemic cells.Semantic proximity Read ↗

Molecular analysis of mutations in the human HPRT gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.