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Article

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

PLoS pathogens - 1 Aug 2017

Zanetti Giulia, Sikorra Stefan, Rummel Andreas, Krez Nadja, Duregotti Elisa, Negro Samuele, Henke Tina, Rossetto Ornella, Binz Thomas, Pirazzini Marco

Abstract excerpt

Botulinum neurotoxin serotype C (BoNT/C) is a neuroparalytic toxin associated with outbreaks of animal botulism, particularly in birds, and is the only BoNT known to cleave two different SNARE proteins, SNAP-25 and syntaxin. BoNT/C was shown to be a good substitute for BoNT/A1 in human dystonia therapy because of its long lasting effects and absence of neuromuscular damage. Two triple mutants of BoNT/C, namely...

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Identifiers

PMID: 28800600
DOI: 10.1371/journal.ppat.1006567
PMCID: PMC5568444

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