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Functional characterisation of tetanus and botulinum neurotoxins binding domains

15 Aug 1999

Abstract excerpt

Tetanus and botulinum neurotoxins constitute a family of bacterial protein toxins responsible for two deadly syndromes in humans (tetanus and botulism, respectively). They bind with high affinity to neurons wherein they cause a complete inhibition of evoked neurotransmitter release. Here we report on the cloning, expression and use of the recombinant fragments of the heavy chains of tetanus neurotoxin and...

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Share to Biochemical and Structural Characterization
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PMID: 10413679
DOI: 10.1242/jcs.112.16.2715

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