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Article

Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators.

The FEBS journal - 1 Dec 2011

Dolly J Oliver, Wang Jiafu, Zurawski Tomas H, Meng Jianghui

Abstract excerpt

A major unmet clinical need exists for long-acting neurotherapeutics to alleviate chronic pain in patients unresponsive to available nonaddictive analgesics. Herein, a new strategy is described for the development of potent and specific inhibitors of the neuronal exocytosis of transmitters and pain mediators that exhibit unique antinociceptive activity. This entailed recombinant production in Escherichia coli of...

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PMID: 21645262
DOI: 10.1111/j.1742-4658.2011.08205.x

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