Article
Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival.
Nature communications - 1 Jan 2013
Peng Lisheng, Liu Huisheng, Ruan Hongyu, Tepp William H, Stoothoff William H, Brown Robert H, Johnson Eric A, Yao Wei-Dong, Zhang Su-Chun, Dong Min
Abstract excerpt
Botulinum neurotoxins (BoNT/A-G) act by blocking synaptic vesicle exocytosis. Whether BoNTs disrupt additional neuronal functions has not been addressed. Here we report that cleavage of syntaxin 1 by BoNT/C, and cleavage of SNAP-25 by BoNT/E both induce degeneration of neurons. Furthermore, although SNAP-25 cleaved by BoNT/A still supports neuron survival, it has reduced capacity to tolerate additional mutations....
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