Article
The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.
The EMBO journal - 15 Apr 1994
Miller M W, Duhl D M, Winkes B M, Arredondo-Vega F, Saxon P J, Wolff G L, Epstein C J, Hershfield M S, Barsh G S
Abstract excerpt
The lethal nonagouti (a(x)) mutation is a hypomorphic allele of the agouti coat color locus which, when homozygous, also leads to embryonic death around the time of implantation. To understand the molecular basis of these phenotypes, we identified and cloned a deletion breakpoint junction present in the ax chromosome. Long range restriction mapping demonstrated a simple deletion of approximately 100 kb, which...
Topics
- Adenosine Deaminase
- Adenosylhomocysteinase
- Agouti Signaling Protein
- Animals
- Base Sequence
- Cloning, Molecular
- Embryonic and Fetal Development
- Genes, Lethal
- Homozygote
- Hydrolases