Article
Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.
Genetics - 1 May 1995
Hustad C M, Perry W L, Siracusa L D, Rasberry C, Cobb L, Cattanach B M, Kovatch R, Copeland N G, Jenkins N A
Abstract excerpt
The agouti locus on mouse chromosome 2 encodes a secreted cysteine-rich protein of 131 amino acids that acts as a molecular switch to instruct the melanocyte to make either yellow pigment (phaeomelanin) or black pigment (eumelanin). Mutations that up-regulate agouti expression are dominant to those causing decreased expression and result in yellow coat color. Other associated effects are obesity, diabetes, and...
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