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Article

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.

Scientific reports - 14 Feb 2017

Hirose Michiko, Hasegawa Ayumi, Mochida Keiji, Matoba Shogo, Hatanaka Yuki, Inoue Kimiko, Goto Tatsuhiko, Kaneda Hideki, Yamada Ikuko, Furuse Tamio, Abe Kuniya, Uenoyama Yoshihisa, Tsukamura Hiroko, Wakana Shigeharu, Honda Arata, Ogura Atsuo

Abstract excerpt

Wild-derived mice have contributed to experimental mouse genetics by virtue of their genetic diversity, which may help increase the chance of identifying novel modifier genes responsible for specific phenotypes and diseases. However, gene targeting using wild-derived mice has been unsuccessful because of the unavailability of stable embryonic stem cells. Here, we report that CRISPR/Cas9-mediated gene targeting...

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Identifiers

PMID: 28195201
DOI: 10.1038/srep42476
PMCID: PMC5307340

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Source receipt: pubmed, retrieved 7 Sept 2026.

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