Article
A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994
Michaud E J, Bultman S J, Klebig M L, van Vugt M J, Stubbs L J, Russell L B, Woychik R P
Abstract excerpt
Lethal yellow (Ay) is a mutation at the mouse agouti locus in chromosome 2 that causes a number of dominant pleiotropic effects, including a completely yellow coat color, obesity, an insulin-resistant type II diabetic condition, and an increased propensity to develop a variety of spontaneous and...
Topics
- Agouti Signaling Protein
- Alleles
- Animals
- Chromosome Mapping
- Diabetes Mellitus, Type 2
- Genes, Dominant
- Genes, Lethal
- Genes, Recessive
- Hair Color
- Intercellular Signaling Peptides and Proteins
- Mice
- Mice, Mutant Strains
- Muridae
- Mutation
- Neoplasms, Experimental