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Article

A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994

Michaud E J, Bultman S J, Klebig M L, van Vugt M J, Stubbs L J, Russell L B, Woychik R P

Abstract excerpt

Lethal yellow (Ay) is a mutation at the mouse agouti locus in chromosome 2 that causes a number of dominant pleiotropic effects, including a completely yellow coat color, obesity, an insulin-resistant type II diabetic condition, and an increased propensity to develop a variety of spontaneous and induced tumors. Additionally, homozygosity for Ay results in preimplantation lethality, which terminates development by...

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Identifiers

PMID: 8146154
DOI: 10.1073/pnas.91.7.2562
PMCID: PMC43409

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A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.PMID 8146154Read ↗

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Molecular characterization of the mouse agouti locus.Semantic proximity Read ↗

The agouti gene: turned on to yellow.Semantic proximity Read ↗

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Neomorphic agouti mutations in obese yellow mice.Semantic proximity Read ↗

Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage.Semantic proximity Read ↗

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.Semantic proximity Read ↗

Effects of the lethal yellow (Ay) mutation in mouse aggregation chimeras.Semantic proximity Read ↗

Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.Semantic proximity Read ↗

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Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.Semantic proximity Read ↗

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