Article
Neomorphic agouti mutations in obese yellow mice.
Nature genetics - 1 Sept 1994
Duhl D M, Vrieling H, Miller K A, Wolff G L, Barsh G S
Abstract excerpt
Several dominant mutations of the mouse agouti coat colour gene have pleiotropic effects that include obesity and a yellow coat. The Ay allele is caused by a large deletion that affects the expression of several contiguous genes. We show that three other obesity-associated agouti mutations, Aiy, Asy and Avy, are due to different molecular alterations that result in ubiquitous expression of a chimaeric RNA that...
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