Article
Neomorphic agouti mutations in obese yellow mice.
Nature genetics - 1 Sept 1994
Duhl D M, Vrieling H, Miller K A, Wolff G L, Barsh G S
Abstract excerpt
Several dominant mutations of the mouse agouti coat colour gene have pleiotropic effects that include obesity and a yellow coat. The Ay allele is caused by a large deletion that affects the expression of several contiguous genes. We show that three other obesity-associated agouti mutations, Aiy,...
Topics
- Agouti Signaling Protein
- Alleles
- Animals
- Base Sequence
- Cloning, Molecular
- Hair Color
- Intercellular Signaling Peptides and Proteins
- Mice
- Mice, Obese
- Molecular Sequence Data
- Mutation
- Proteins