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The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein.

Genes & development - 1 Jul 1993

Michaud E J, Bultman S J, Stubbs L J, Woychik R P

Abstract excerpt

Lethal yellow (Ay) is a mutation at the mouse agouti (a) locus that is associated with an all-yellow coat color, obesity, diabetes, tumors in heterozygotes, and preimplantation embryonic lethality in homozygotes. Previously, we cloned and characterized the wild-type agouti gene and demonstrated t...

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Mutation
Molecular Sequence Data
Base Sequence
Amino Acid Sequence
Mice
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

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PMID: 8319910
DOI: 10.1101/gad.7.7a.1203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8319910-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein.PMID 8319910Read ↗

A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.Semantic proximity Read ↗

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.Semantic proximity Read ↗

Molecular characterization of the mouse agouti locus.Semantic proximity Read ↗

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Overexpression of an Agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants.Semantic proximity Read ↗

Epigenetic inheritance at the agouti locus in the mouse.Semantic proximity Read ↗

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The agouti gene: turned on to yellow.Semantic proximity Read ↗

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Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.Semantic proximity Read ↗

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