Article
Intragenic Tsc2 somatic mutations as Knudson's second hit in spontaneous and chemically induced renal carcinomas in the Eker rat model.
Japanese journal of cancer research : Gann - 1 Mar 1997
Kobayashi T, Urakami S, Hirayama Y, Yamamoto T, Nishizawa M, Takahara T, Kubo Y, Hino O
Abstract excerpt
We searched for the rat homologue of the human tuberous sclerosis (TSC2) gene mutations in loss of heterozygosity (LOH)-negative Eker rat renal carcinomas (RCs) by polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) analysis using 45 primer sets covering all 41 coding e...
Topics
- Alleles
- Animals
- Chromosome Deletion
- DNA Primers
- DNA Transposable Elements
- Ethylnitrosourea
- Frameshift Mutation
- Genes, Tumor Suppressor
- Humans
- Introns
- Kidney Neoplasms
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational