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Article

Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.

Molecular carcinogenesis - 1 Sept 1995

Yeung R S, Xiao G H, Everitt J I, Jin F, Walker C L

Abstract excerpt

Somatic events leading to the inactivation of tumor suppressor genes often involve chromosomal alterations that can be detected as loss of heterozygosity (LOH). In the Eker rat, spontaneous tumors of the kidney, uterus, and spleen develop as a result of a germline mutation of the tuberous sclerosis 2 (Tsc2) gene. We examined the pattern and frequency of LOH at the predisposing locus in 77 primary tumors and cell...

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PMID: 7546222
DOI: 10.1002/mc.2940140107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.PMID 7546222Read ↗

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