Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.

doi:10.1002/mc.2940140107

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Article

Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.

Molecular carcinogenesis - 1 Sept 1995

Yeung R S, Xiao G H, Everitt J I, Jin F, Walker C L

Abstract excerpt

Somatic events leading to the inactivation of tumor suppressor genes often involve chromosomal alterations that can be detected as loss of heterozygosity (LOH). In the Eker rat, spontaneous tumors of the kidney, uterus, and spleen develop as a result of a germline mutation of the tuberous scleros...

Topics

Alleles
Animals
Base Sequence
Blotting, Northern
Carcinoma, Renal Cell
Cell Line
Chromosome Deletion
DNA Primers
Exons
Female
Genes, Tumor Suppressor
Hemangiosarcoma
Kidney Neoplasms
Leiomyoma
Models, Genetic
Molecular Sequence Data
Polymerase Chain Reaction
Rats

Source

Open in PubMed

Identifiers

PMID: 7546222
DOI: 10.1002/mc.2940140107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7546222-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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