The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene.

doi:10.1006/bbrc.1994.2324

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Article

The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene.

Biochemical and biophysical research communications - 15 Sept 1994

Hino O, Kobayashi T, Tsuchiya H, Kikuchi Y, Kobayashi E, Mitani H, Hirayama Y

Abstract excerpt

The Eker rat is a promising animal model of cancer predisposition syndromes. In this study, using 129 backcross animals, we have established a new conserved linkage group on rat 10q and human 16p13.3 whereby the Eker mutation was found to be tightly linked to the tuberous sclerosis (TSC2) gene. T...

Topics

Animals
Base Sequence
Female
Genetic Linkage
Humans
Male
Molecular Sequence Data
Mutation
Neoplasms, Experimental
Neoplastic Syndromes, Hereditary
Polymorphism, Restriction Fragment Length
Rats
Rats, Inbred BN
Rats, Mutant Strains
Tuberous Sclerosis

Source

Open in PubMed

Identifiers

PMID: 7916573
DOI: 10.1006/bbrc.1994.2324

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7916573-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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