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Article

Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.

Japanese journal of cancer research : Gann - 1 Sept 1995

Kubo Y, Kikuchi Y, Mitani H, Kobayashi E, Kobayashi T, Hino O

Abstract excerpt

Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extra-renal primary tumors co-occurring in Eker rats late in life (at 2 years) additionally revealed enhanced development of hemangiosarcomas of the spleen, uterine leiomyosarcomas and pituitary adenomas, although the demonstrated predilection for these extra-renal tumors was not as complete as with RCs....

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Identifiers

PMID: 7591959
DOI: 10.1111/j.1349-7006.1995.tb03092.x
PMCID: PMC5920926

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