Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.

doi:10.1111/j.1349-7006.1995.tb03092.x

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Article

Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.

Japanese journal of cancer research : Gann - 1 Sept 1995

Kubo Y, Kikuchi Y, Mitani H, Kobayashi E, Kobayashi T, Hino O

Abstract excerpt

Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extra-renal primary tumors co-occurring in Eker rats late in life (at 2 years) additionally revealed enhanced development of hemangiosarcomas of the spleen, uterine leiomyosarcomas and pi...

Topics

Adenoma
Alleles
Animals
Base Sequence
DNA, Neoplasm
Disease Models, Animal
Female
Gene Deletion
Heterozygote
Leiomyosarcoma
Male
Molecular Sequence Data
Pituitary Neoplasms
Rats
Rats, Mutant Strains
Tuberous Sclerosis
Uterine Neoplasms

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Identifiers

PMID: 7591959
DOI: 10.1111/j.1349-7006.1995.tb03092.x
PMCID: PMC5920926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7591959-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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