Article
A mutation of the mu transmembrane that disrupts endoplasmic reticulum retention. Effects on association with accessory proteins and signal transduction.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1994
Stevens T L, Blum J H, Foy S P, Matsuuchi L, DeFranco A L
Abstract excerpt
The mu heavy chain has an unusually high content of hydroxyl-containing amino acids in its membrane-spanning region. We have examined the involvement of two of these hydrophilic residues in endoplasmic reticulum (ER) retention, interactions with Ig-alpha/Ig-beta, and transmembrane signaling. Neig...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Anti-Idiotypic
- B-Lymphocytes
- Base Sequence
- Cell Line
- DNA
- Endoplasmic Reticulum
- Goats
- Immunoglobulin mu-Chains
- Mice
- Molecular Sequence Data
- Mutation
- Proteins
- Rabbits
- Receptors, Antigen, B-Cell
- Signal Transduction
- Transfection