Article
The role of Ig-α/β in B cell antigen receptor internalization.
Immunology letters - 30 Nov 2010
Jang Caren, Machtaler Steven, Matsuuchi Linda
Abstract excerpt
The B cell antigen receptor (BCR) is expressed on the surface of B lymphocytes where it can bind antigen then transmit signals which regulate activation, growth, and differentiation. These signals can induce a number of cytoskeletal rearrangements leading to dynamic cellular processes including internalization of the bound antigen which is then processed and presented to T cells on MHC II. The relative importance...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Blotting, Western
- CD79 Antigens
- Cell Line, Tumor
- Endocytosis
- Endosomes
- Lysosomes
- Mice
- Microscopy, Confocal
- Mutation