Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transmembrane tyrosine of micro-heavy chain is required for BCR destabilization and entry of antigen into clathrin-coated vesicles.

International immunology - 1 Dec 2007

Kim Jin Hyang, Rutan Jennifer A, Vilen Barbara J

Abstract excerpt

The B cell antigen receptor (BCR) delivers antigen to the endocytic compartment and transduces signals that regulate the stability of the receptor complex. Previous studies showed that BCR-mediated signal transduction dissociates micro-heavy chain (microm) from Ig-alpha/Ig-beta, facilitating the delivery of antigen to clathrin-coated vesicles (CCVs). Herein, we demonstrate that the dissociation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Antigens
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Lysosomal Membrane Proteins

Share to Microscopy, Electron, Transmission

Share to Receptors, Antigen, B-Cell

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 17981794
DOI: 10.1093/intimm/dxm110
PMCID: PMC3716379

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transmembrane tyrosine of micro-heavy chain is required for BCR destabilization and entry of antigen into clathrin-coated vesicles.PMID 17981794Read ↗

The Ins and Outs of Antigen Uptake in B cellsSemantic proximity Read ↗

Structurally distinct endocytic pathways for B cell receptors in B lymphocytesSemantic proximity Read ↗

Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in Diffuse Large B Cell Lymphoma (DLBCL)Semantic proximity Read ↗

Internalization of the lymphocytic surface protein CD22 is controlled by a novel membrane proximal cytoplasmic motif.Semantic proximity Read ↗

Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.Semantic proximity Read ↗

Structurally distinct endocytic pathways for B cell receptors in B lymphocytesSemantic proximity Read ↗

Tyrosine-containing sequence motifs of the human immunoglobulin G receptors FcRIIb1 and FcRIIb2 essential for endocytosis and regulation of calcium flux in B cells.Semantic proximity Read ↗

Defining MacropinocytosisSemantic proximity Read ↗

Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization.Semantic proximity Read ↗

An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat ComplexSemantic proximity Read ↗

Aberrant trafficking of the B cell receptor Ig-alpha beta subunit in a B lymphoma cell line.Semantic proximity Read ↗

Dissection of the trans-endocytosis and signal inhibition functions of CTLA-4 through the study of a disease-associated Y139C mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.