Article
Early B cell development requires mu signaling.
European journal of immunology - 1 Oct 1993
Iglesias A, Nichogiannopoulou A, Williams G S, Flaswinkel H, Köhler G
Abstract excerpt
In vitro studies with Abelson murine leukemia virus (AMuLV)-transformed murine pre-B cell lines demonstrated that wild-type mu but not mutant mu chains lacking the first constant domain (mu delta 1) can efficiently induce Ig light (L) chain gene rearrangement. Using antibodies against the cytopla...
Topics
- Abelson murine leukemia virus
- Animals
- Antigens, CD
- B-Lymphocytes
- CD79 Antigens
- Cell Differentiation
- Cell Line, Transformed
- Glycosylphosphatidylinositols
- Hybridomas
- Immunoglobulin mu-Chains
- Mice
- Mice, Transgenic
- Mutation
- Receptors, Antigen, B-Cell
- Signal Transduction