Article
Endosomal targeting by the cytoplasmic tail of membrane immunoglobulin.
Science (New York, N.Y.) - 18 Apr 1997
Weiser P, Müller R, Braun U, Reth M
Abstract excerpt
Membrane-bound immunoglobulin (mIg) of the IgG, IgA, and IgE classes have conserved cytoplasmic tails. To investigate the function of these tails, a B cell line was transfected with truncated or mutated gamma2a heavy chains. Transport to the endosomal compartment of antigen bound by the B cell an...
Topics
- Animals
- Antigen Presentation
- B-Lymphocytes
- Biological Transport
- Cytoplasm
- Dimerization
- Endosomes
- Immunoglobulin gamma-Chains
- Immunologic Memory
- Mice
- Mutation
- Receptors, Antigen, B-Cell
- Recombinant Fusion Proteins