Article
Endosomal targeting by the cytoplasmic tail of membrane immunoglobulin.
Science (New York, N.Y.) - 18 Apr 1997
Weiser P, Müller R, Braun U, Reth M
Abstract excerpt
Membrane-bound immunoglobulin (mIg) of the IgG, IgA, and IgE classes have conserved cytoplasmic tails. To investigate the function of these tails, a B cell line was transfected with truncated or mutated gamma2a heavy chains. Transport to the endosomal compartment of antigen bound by the B cell antigen receptor did not occur in the absence of the cytoplasmic tail; and one or two mutations, respectively, in the...
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