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Article

Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo.

Blood - 27 May 2010

Krysov Sergey, Potter Kathleen N, Mockridge C Ian, Coelho Vania, Wheatley Isla, Packham Graham, Stevenson Freda K

Abstract excerpt

Surface IgM (sIgM) has a key influence on the clinical behavior of chronic lymphocytic leukemia (CLL). We now report that it exists in 2 forms with different N-glycosylation patterns in the mu-constant region. One glycoform is similar to normal B cells in bearing mature complex glycans common to most cell-surface glycoproteins. The other is an immature mannosylated form more characteristic of mu chains in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20237321
DOI: 10.1182/blood-2009-12-254847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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