Article
Mutations within the NH2-terminal transmembrane domain of membrane immunoglobulin (Ig) M alters Ig alpha and Ig beta association and signal transduction.
The Journal of biological chemistry - 30 Sept 1994
Michnoff C H, Parikh V S, Lelsz D L, Tucker P W
Abstract excerpt
Potentiation of initial signal transduction events through the cross-linking of the B cell antigen receptor complex appears to be dependent upon the association of membrane immunoglobulin (mIg) with Ig alpha and Ig beta. We made two groups of mutations within the COOH terminus of mIgM substitutin...
Topics
- Amino Acid Sequence
- Antigens, CD
- B-Lymphocytes
- CD79 Antigens
- Calcium
- Cell Membrane
- Immunoglobulin M
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Phosphoproteins
- Phosphorylation
- Receptors, Antigen, B-Cell
- Receptors, Fc
- Signal Transduction
- Tumor Cells, Cultured
- Tyrosine