Article
Aberrant trafficking of the B cell receptor Ig-alpha beta subunit in a B lymphoma cell line.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2000
Condon C, Hourihane S L, Dang-Lawson M, Escribano J, Matsuuchi L
Abstract excerpt
The B cell Ag receptor (BCR) has two important functions: first, it binds and takes up Ag for presentation to T lymphocytes; and second, it transmits signals that regulate B cell development. Normal expression of the BCR requires the association of the Ag binding subunit, membrane IgM (mIgM), with the signaling component, the Ig-alpha beta heterodimer. After assembly in the endoplasmic reticulum, the intact BCR...
Topics
- Animals
- Antigens, CD
- Biological Transport
- CD79 Antigens
- Cell Membrane
- Cricetinae
- Hexosaminidases
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin M
- Immunoglobulin mu-Chains
- Lymphoma, B-Cell
- Membrane Glycoproteins
- Mice
- Mutation
- Receptors, Antigen, B-Cell
- Sequence Analysis, DNA