p53 gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis.

doi:10.1111/1523-1747.ep12373002

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Article

p53 gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis.

The Journal of investigative dermatology - 1 Apr 1994

Kubo Y, Urano Y, Yoshimoto K, Iwahana H, Fukuhara K, Arase S, Itakura M

Abstract excerpt

Mutations of exons 3 through 9 of the p53 gene in skin lesions were screened in 23 cases of squamous cell carcinoma (SCC), 25 cases of basal cell carcinoma (BCC), two cases of Bowen's disease, 10 cases of solar keratosis, and five cases of keratoacanthoma by polymerase chain reaction--single strand conformation polymorphism analysis. Mutations of the p53 gene were detected in seven of 23 SCCs (30%), three of 25...

Topics

Aged
Aged, 80 and over
Base Sequence
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
DNA, Single-Stranded
Exons
Female
Genes, p53
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 8151121
DOI: 10.1111/1523-1747.ep12373002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8151121-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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