p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin.

doi:10.1111/1523-1747.ep12475717

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Article

p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin.

The Journal of investigative dermatology - 1 Jun 1993

Campbell C, Quinn A G, Ro Y S, Angus B, Rees J L

Abstract excerpt

Mutations of the p53 gene are the most common genetic abnormality described in human cancer; p53 mutations have recently been reported in more than half of the cases of squamous cell carcinomas of the skin. We have previously reported positive p53 immunostaining in Bowen's disease and actinic ker...

Topics

Base Sequence
Bowen's Disease
Carcinoma, Squamous Cell
Female
Genes, p53
Humans
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Skin Neoplasms

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