Aberrations of the tumor suppressor p53 gene and p53 protein in solar keratosis in human skin.

doi:10.1111/1523-1747.ep12395643

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Article

Aberrations of the tumor suppressor p53 gene and p53 protein in solar keratosis in human skin.

The Journal of investigative dermatology - 1 Oct 1994

Taguchi M, Watanabe S, Yashima K, Murakami Y, Sekiya T, Ikeda S

Abstract excerpt

Aberrations of the p53 gene in 27 solar keratoses were examined by the polymerase chain reaction and single-strand conformation polymorphism and DNA sequencing analyses. In a series of Japanese patients, eight of 27 cases (30%) of solar keratosis showed structural abnormalities of the p53 gene. S...

Topics

Base Sequence
Chromosome Aberrations
Genes, p53
Humans
Immunohistochemistry
Keratosis
Molecular Sequence Data
Mutation
Polymorphism, Single-Stranded Conformational
Tumor Suppressor Protein p53
Ultraviolet Rays

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