Article
p53 gene mutations in squamous cell carcinoma occurring in scars: comparison with p53 protein immunoreactivity.
The American Journal of dermatopathology - 1 Oct 1998
Sakatani S, Kusakabe H, Kiyokane K, Suzuki K
Abstract excerpt
We determined the relationship between p53 expression and p53 gene mutations in squamous cell carcinoma occurring in scars and unrelated to UV light irradiation. We analyzed biopsy specimens obtained from three patients with squamous cell carcinoma. A monoclonal antibody against p53 (DO-7) was used for the immunohistochemical analysis. p53 gene mutations were detected by the polymerase chain reaction and...
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