Article
Expression of p53 protein is an early event in ultraviolet light-induced cutaneous squamous cell carcinogenesis.
Archives of dermatology - 1 Sept 1993
Nagano T, Ueda M, Ichihashi M
Abstract excerpt
BACKGROUND AND DESIGN: p53 Is known to be a tumor-suppressor gene and has been suggested to play an important role for multistep carcinogenesis of cutaneous squamous cell carcinoma (SCC). To evaluate the role of ultraviolet light (UV) in p53 mutation in squamous cell carcinogenesis, paraffin-embedded sections of SCCs were immunohistochemically stained with the CM-1 antibody for p53 protein. Positive staining...
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