Article
Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers.
Cancer letters - 30 Sept 1994
Nelson M A, Einspahr J G, Alberts D S, Balfour C A, Wymer J A, Welch K L, Salasche S J, Bangert J L, Grogan T M, Bozzo P O
Abstract excerpt
A biomarker of skin cancer would be beneficial in evaluating the efficacy of potential cancer chemoprevention agents. To this end, we investigated the tumor suppressor gene p53 in precancerous actinic keratosis lesions (AK) and malignant squamous cell carcinomas (SCCs) using polymerase chain reac...
Topics
- Base Sequence
- Biopsy
- Carcinoma, Squamous Cell
- Exons
- Genes, p53
- Humans
- Immunohistochemistry
- Keratosis
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Precancerous Conditions
- Skin Neoplasms
- Tumor Suppressor Protein p53