Article
Apolipoprotein E genetic variation and Alzheimer's disease. a meta-analysis.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Rubinsztein D C, Easton D F
Abstract excerpt
In order to quantify the effects of apolipoprotein (apo) E on early- and late-onset, sporadic and familial Alzheimer's disease (AD) more precisely we performed a meta-analysis of 42 case-control series published before July 1996. We excluded studies of late-onset AD with fewer than 50 cases and 50 controls. The estimated odds ratio of AD over the age of 65 years associated with the apo epsilon4 allele, relative...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Cross-Sectional Studies
- Genetic Variation
- Genotype
- Humans