Article
Contrasting morphological changes in PC12 flat cells expressing two different forms of exogenous oncogenic ras.
Experimental cell research - 1 Mar 1994
Rozenberg Y Y, Howard B D
Abstract excerpt
Oncogenic ras is known to transform certain cells, whereas it induces terminal differentiation of others, e.g., neuronal differentiation of PC12 cells. MPT1 is a PC12 flat cell variant that extends glial-like processes and exhibits some properties of noncancer cells in culture, e.g., absence of anchorage-independent growth. Expression of oncogenic ras by MPT1 cells failed to result in neuronal differentiation,...
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