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Article

Morphologic conversion of a neuroblastoma-derived cell line by E6-mediated p53 degradation.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 2001

Gaitonde S V, Qi W, Falsey R R, Sidell N, Martinez J D

Abstract excerpt

Neuroblastoma-derived tumor cells, unlike cells from other tumor types, characteristically express a wildtype but cytoplasmically sequestered p53 protein. To ascertain whether the p53 in these cells retained any physiological activity, we inactivated it in SK-N-SH cells, a neuroblastoma-derived cell line, by introducing the human papilloma virus type 16 E6 expression plasmid. Parent SK-N-SH cell cultures are...

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PMID: 11205742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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