Article
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-resistant, flat-cell PC12 variants having a partial loss of transformed phenotype.
Journal of neurochemistry - 1 Aug 1990
Andersen J K, Zhang M B, Zhong X H, Rozenberg Y Y, Howard B D
Abstract excerpt
We have cloned and characterized two variants of PC12 cells. MPT1 cells were selected by their resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and variant 2068 was isolated nonselectively as a large, flat-cell variant commonly occurring in PC12 cultures. Variant 2068 cells also...
Topics
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Adrenal Gland Neoplasms
- Animals
- Cell Transformation, Neoplastic
- Drug Resistance
- Gene Expression
- Genetic Variation
- Glycolysis
- Isoenzymes
- Karyotyping
- L-Lactate Dehydrogenase
- Lactates
- Lactic Acid
- Mitochondria
- Phenotype
- Pheochromocytoma
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-fos