Article
Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts.
The international journal of biochemistry & cell biology - 1 Jan 1998
Tabib A, Bachrach U
Abstract excerpt
Previous studies have demonstrated that polyamines accumulate in cancer cells and that overproduction of ornithine decarboxylase (ODC), which catalyzes polyamine synthesis, elicits the acquisition of the transformed phenotype. However, it was not clear whether the overexpression of ODC and the ac...
Topics
- 3T3 Cells
- Animals
- Antineoplastic Agents, Hormonal
- Blotting, Western
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Dexamethasone
- Eflornithine
- Enzyme Inhibitors
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Mammary Tumor Virus, Mouse
- Mice
- Ornithine Decarboxylase
- Phenotype
- Polyamines
- Promoter Regions, Genetic