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Article

Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts.

The international journal of biochemistry & cell biology - 1 Jan 1998

Tabib A, Bachrach U

Abstract excerpt

Previous studies have demonstrated that polyamines accumulate in cancer cells and that overproduction of ornithine decarboxylase (ODC), which catalyzes polyamine synthesis, elicits the acquisition of the transformed phenotype. However, it was not clear whether the overexpression of ODC and the accumulation of polyamines are only innocent by-products of the transformation process. In this study we demonstrate that...

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PMID: 9597759
DOI: 10.1016/s1357-2725(97)00073-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts.PMID 9597759Read ↗

Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.Semantic proximity Read ↗

K-FGF mediated transformation and induction of metastatic potential involves altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression--role in cellular invasion.Semantic proximity Read ↗

Altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression and regulation in mouse fibroblasts transformed with oncogenes or constitutively active Mitogen-Activated Protein (MAP) kinase kinase.Semantic proximity Read ↗

Molecular mechanisms of polyamine analogs in cancer cellsSemantic proximity Read ↗

Activation of the proto-oncogene c-myc and c-fos by c-ras: involvement of polyamines.Semantic proximity Read ↗

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.Semantic proximity Read ↗

Differentiation of a mouse neuroblastoma variant cell line whose ornithine decarboxylase gene has been amplified.Semantic proximity Read ↗

Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.Semantic proximity Read ↗

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.Semantic proximity Read ↗

Phenotypic features of breast cancer cells overexpressing ornithine-decarboxylase.Semantic proximity Read ↗

Asparagine markedly induces the expression of ornithine decarboxylase gene in transformed mammalian cells but not in their untransformed counterparts.Semantic proximity Read ↗

Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme.Semantic proximity Read ↗

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