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Article

V-K-ras transformation induces reversion to an earlier developmental form in adult rat adrenal cells.

Differentiation; research in biological diversity - 1 Mar 1990

Auersperg N, MacLaren I A, Bissell M J

Abstract excerpt

The basis for specific changes in differentiation that accompany ras-oncogene-mediated transformation are not understood. When short-term cultures of fibroblast-like cells from adult rat adrenal glands were transformed with Kirsten murine sarcoma virus (KiMSV), the original stromal characteristics of the target cells (metachromatic extracellular matrix, high collagen production, collagen incorporation into...

Topics

20-Hydroxysteroid Dehydrogenases
Adrenal Glands
Animals
Cell Transformation, Viral
Cells, Cultured
Collagen
Extracellular Matrix
Genes, ras
Lipids
Phenotype
Precipitin Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins

Proto-Oncogene Proteins p21(ras)

Rats

Transformation, Genetic

Source

Identifiers

PMID: 2194873
DOI: 10.1111/j.1432-0436.1990.tb00427.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2194873-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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